EXTRACT OF Morinda lucida LEAF RESCUES HYPOGLYCAEMIC AND DYSLIPIDAEMIC CONDITIONS IN Plasmodium berghei-INFECTED MICE

Authors

Adam Olaitan Abdulkareem

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria; Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India

Abdulkareem Olarewaju Babamale

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria; Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming Chiao Tung University and Academia Sinica, Taipei Taiwan

Abass Toba Anifowoshe

Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India; Department of Zoology, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria

Olufunke Adenike Opeyemi

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Nusirat Oloriegbe

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Comfort Adamolekun

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Samson Adetula

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Adeola Adefoluke Ala

Animal Physiology Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria

DOI 10.5937/bnsr12-35454 Original page Cite this article

Keywords

Malaria, Hypoglycaemia, Dyslipidaemia, Morinda lucida, Plasmodium berghei

Abstract

Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important. In this study, we investigated the anti-hypoglycaemic and anti-hyperlipidaemic effects of aqueous extract of Morinda lucida leaf in Plasmodium berghei-infected mice. Twenty-five mice were randomly grouped into five: Uninfected, infected-untreated, chloroquine (20 mg/kg, per oral), and extract-treated (400 mg/kg and 800 mg/kg, respectively, per oral) groups. Fasting blood glucose was measured before parasite inoculation and after the last treatment. Blood was collected for lipid profile assay at the end of the 4-day treatment. Our results revealed that both chloroquine and the extract lowered parasite growth (p

Published

2022/09/11

Issue

Vol. 12 No. 2 (2022)

Pages

1-6.

Section

Original Scientific Paper

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