SYNTHESIS AND COMPLETE NMR SPECTRAL ASSIGNMENTS OF NEW BENZYLAMINO COUMARIN DERIVATIVE

Authors

Vidoslav Dekić

Faculty of Sciences, University in Priština - Kosovska Mitrovica, Kosovska Mitrovica, Serbia

Niko Radulović

Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Niš, Serbia

Milenko Ristić

Faculty of Sciences and Mathematics, University of Priština in Kosovska Mitrovica, Serbia

Biljana Dekić

Faculty of Sciences and Mathematics, University of Priština in Kosovska Mitrovica, Kosovska Mitrovica, Serbia

Novica Ristić

Faculty of Sciences, University in Priština - Kosovska Mitrovica, Kosovska Mitrovica, Serbia

DOI 10.5937/bnsr10-26133 Original page Cite this article

Keywords

Coumarins, Synthesis, Spectral analysis, 1H NMR, 13C NMR, 2D NMR

Abstract

This research involves the reaction of 4-chloro-3-nitrocoumarin and (4-methoxyphenyl)methanamine, whereby a novel coumarin derivative 4-[(4-methoxybenzyl) amino]-3-nitro-2H-chromen-2-one was obtained in good yield. The reaction was carried out in ethyl acetate, in the presence of triethylamine. Also, a detailed spectral analysis of a new coumarin derivative is presented. Resonance assignment was achieved using one- (1H NMR and 13C NMR) and two-dimensional NMR techniques (1H-1H-COSY, NOESY, HSQC, and HMBC). The NOESY correlations of protons from arylamino substituent and coumarin core indicate their spatial orientation.

Published

2020/06/17

Issue

Vol. 10 No. 2 (2020)

Pages

12-16.

Section

Original Scientific Paper

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